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The SELECT trial (Semaglutide Effects on Heart Disease and Stroke in Patients With Overweight or Obesity), a phase 3 study involving 17,604 adults with overweight or obesity and pre-existing CVD but no diabetes, revealed that once-weekly subcutaneous semaglutide 2.4 mg reduced the risk of major adverse cardiovascular events by 20% compared with placebo over a mean follow-up of 39.8 months, including cardiovascular death, nonfatal myocardial infarction, and nonfatal stroke [48]

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Genetics and individual metabolism There is emerging evidence that genetic variations in GLP-1 receptor expression and sensitivity affect both the therapeutic response to semaglutide and the side effect profile

As with any prescription medication, semaglutide may involve risks and side effects

Wegovy (semaglutide injection): Another weekly option, Wegovy is designed for individuals dealing with obesity or overweight conditions with associated health concerns