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Tirzepatide is contraindicated in patients with a personal or family history of medullary thyroid cancer or multiple endocrine neoplasia 2, a condition that increases the risk for medullary thyroid cancer Routine monitoring with serum calcitonin or thyroid ultrasound is of uncertain value and will likely lead to many incidental findings and unnecessary procedures

Subcutaneous injection technique: pinch skin to create a fold, insert needle at 4590 angle, inject slowly over 510 seconds, withdraw needle, apply light pressure (do not rub)

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Fasted subjects showed peak GH levels 2.8 higher than fed subjects receiving identical doses