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10.1038/clpt.2012.64 5 BenowitzN.DempseyD

But tobacco that is smokeless is not harmless. It contains at least 28 carcinogens and causes oral, pancreatic, and esophageal cancer, along with serious health problems such as heart disease, gum disease, tooth decay, and mouth lesions

The nicotine content is kept minimal, which helps avoid the dizziness or coughing often associated with stronger brands

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Use of the specific PARP-1 inhibitor, BMN673, abrogated the effect of smoke induced activation of the parthanatos pathway