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"Certainly those two chemicals are known to be problematic," said James Pankow, a chemistry professor with Portland State University in Oregon who has studied e-liquids

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Increasing the resources available to prevent this could result in increased revenue in addition to furthering efforts to reduce youth smoking

They found that, although the research is sparse, what has been published indicates "consistent evidence for the presence of at least four substance abuse disorder criteria in heavy N2O [nitrous oxide] users." The authors concluded that nitrous oxide "could well be addictive." They advised that it should be handled as a "potentially addictive substance" until more assessments are conducted