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Indeed, nicotine is responsible for both positive, such as psychoactive stimulation, and negative effects, such as discomfort and uneasiness [13]

In 1999, 19% of 15-20 year old men and 4.3% of 15-20 year old women identified themselves as smokers

As such, we assume that under-reporting of smoking prevalence is not a major concern for our study and that any changes in the rate of under-reporting varies identically across all states and follows a linear trend

ENVIRONMENTAL INFLUENCES ON DNA METHYLATION Methylation of DNA may also be modified by environmental factors (Terry et al., 2011)