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First, the presented risk equivalencies do not take into account the following factors which may interact with alcohol and tobacco: harms to others, disability, non-health harms, and differences in an persons risk factors For example, both alcohol and tobacco carry risks for second-hand harms through non-user exposurei.e., increased risk of alcohol-related injuries (e.g., motor vehicle accidents) or secondhand exposure due to drifting tobacco smoke ( Second, alcohol and tobacco have been noted to interact and share risk factorse.g., and further interactions through co-use have been shown to exponentially increase the risk of head and neck cancers ( Third and lastly, the data analysis and modeling employed in this study have several limitations

There have been significant non-tobacco alternatives including NRT, pharmacological support, behavioral support, and regulation for decades

Only moderate smokers and former tobacco product users should use a 6mg pouch

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