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When John Wayne was seen enjoying a cigar, it usually seemed to be just that: a moment of enjoyment, relaxation or contemplation

Its reference to simple, beloved themes of freedom and the Wild West make the character so iconic that it becomes an instantly recognizable substitute for the product itself

Take a photo of it if you are prone to losing things

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If the protocol dictated EC use for 5 minutes only, with a subsequent abstinence period, it is possible that participants would have used the devices more intensively since they would have little time to satisfy their nicotine need, resulting in higher plasma nicotine levels