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The report by Vital Strategies and the Tobacconomics team at the University of Illinois at Chicago, U.S, noted that tobacco usage of smokeless and smoked products together led to 8.67 million deaths worldwide in 2019, with economic damages worth approximately US $2 trillion

Salivary cotinine and anabasine concentrations will be determined by liquid chromatography-tandem mass spectrometry (LC-MS/MS) assay