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Besides, more in-depth studies are needed to explore the effects of smoking on other enzymes, such as CYP3A4, and on renal transporters, as well as the possibility of monitoring and tailoring drug dosages by phenotypic and genotypic tests (e.g

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These cigarettes were designed with tiny ventilation holes in the filters, which dilute the smoke with air and make it seem less harsh

Smoke after a meal rather than on an empty stomach

To gather evidence for each step in this causal chain of events, a combination of aerosol chemistry, non-clinical studies, and clinical studies can be used (Fig