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Tobacco is one of the most common preventable risk factors of premature morbidity and mortality all over the world

Causes can include: Not drinking enough water throughout the day Excess sweating from heat or exercise Caffeine or alcohol intake Illness with fever, vomiting, or diarrhea Sometimes people drink fluids but still feel thirsty because theyre not replacing electrolytes properly, especially after sweating

Immunblots were performed from cell lysate to analyze the expression of different cell cycle and apoptotic markers, such as, p53, p21, Bax, Bcl-2 and from serum to measure the level of different pro-inflammatory cytokines, such as, IL-6, TNF-, iNOS, Cox-2