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They contradicted statements made by the tobacco CEOs, for example, that nicotine was kept in tobacco simply for the flavor rather than for its addictive impact.[13] They showed evidence from their experiments that when rats were taught to press a lever to receive an injection of nicotine, they increasingly did so, demonstrating not only addictive behavior, but also how users build up nicotine tolerance over time.[14] A few days after the hearing, the subcommittee obtained documents from a public relations firm retained by the tobacco industrys trade association to combat anti-tobacco criticism and legislation

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These structural alterations decrease the activation threshold of sensory neurons and bring them into closer proximity to environmental stimuli, thereby increasing susceptibility to light touch, allergens, and chemical irritants and facilitating itch responses (84)

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