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The original study by Philip Morris, called Project Mix, resulted in the publication of four papers in a scientific journal that concluded there was "no evidence of substantial toxicity" associated with the additives studied

Creatinine A waste product from normal metabolism that is commonly used as a denominator in biomarker studies

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Gelatin capsules that contain flavoring are embedded in the cigarette filter, and pressing the filter to crush the capsule releases the flavor into the smoke

Nicotine triggers the release of several neurotransmitters in the brain, notably dopamine, which stimulates a sense of pleasure and well-being