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Richard Doll and Professor Bradford Hill conducted a case-control study in which lung cancer, other cancer, and non-cancer patients from twenty London-area hospitals were interviewed about their smoking habits

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In this line, results from GCMS and HPLC analyses indicated that cinnamaldehyde (CAD) and 2-methoxycinnamaldehyde, but not dipropylene glycol or vanillin, were mainly responsible for the high cytotoxicity of cinnamon-flavoured e-liquids [80]