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has considerably decreased since fiscal year 2014, down more than 10 percentage points over the last ten years, reportedly from 55% in 2014 to 42.8% as of 2023

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At this point, we are not able to suggest any plausible explanation for the CSE cytoskeletal effect, but it is well known that CSE contains many elements that could potentially have a direct effect on microtubules or actin assembly