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There have been questions as to whether varenicline can cause symptoms of depression, suicidal thoughts, agitation, and aggression, though research suggests that while all of these problems can occur when people try to quit smoking, none of them occur more frequently among people taking varenicline than those assigned placebo

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But based on a study in rats published in the Journal of the American Heart Association (JAHA), it appears that exposure to secondhand cannabis smoke does pose health and safety risks