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Both stimulants and depressants are frequently abused, and people can easily develop dependence and addiction

DragonFable : The ironically named "Crystal Clear Lake" is a murky swamp with mobs there including a Man-Thing-esque monster called the Swamp Shambler, as well as a Gill Man-type creature called the Lagoon Goon

Toshio invented a yubiwa pipe with a hole people could insert cigarettes into to allow them to smoke while working with their hands

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