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To evaluate linearity in the dose-response relationship, a Wald test was conducted on three dose categories across four notes (5, 35, 65, 95 percentile) by segmenting smoking (pack-years)

Biochemical verification of tobacco use and abstinence: 2019 update

So it doesnt necessarily reduce the smoking of old-fashioned cigarettes. This may be partly due to how the body absorbs nicotine

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"The FDA does not approve these products as tobacco cessation interventions or nicotine replacement medications, so I would not recommend them," says Kecia Christensen, APRN-NP, Nebraska Medicine certified tobacco treatment specialist