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SLT products range in complexity from tobacco-only, to products containing numerous chemical ingredients and additives.[] This article deals specifically with the chemistry and toxic effects of smokeless tobacco products

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Dopamine is associated with pleasure and reward, which reinforces nicotines addictive nature

Now those who wanted to switch away from smoking had an alternative that could satisfy their needs without the risks posed to their health by cigarettes

relapse from smoking, as self-reported abstinence may not correctly reflect actual abstinence from smoking