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Years of clinical research, the FDA says, have shown that "some warnings and limitations specified in the directions for use on the labels of these products are no longer necessary to make sure they are used safely and effectively to quit smoking." To that end FDA is allowing the companies who make these OTC products to make several changes to the warnings and limitations in the directions for use on their labels to allow some flexibility on how they are used and for how long

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The researchers have found that CBD could inhibit the metabolism of nicotine by influencing the enzyme CYP2A6 [8]