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So p53 comes to the defenseit promotes apoptosis of cells with damaged DNA, thereby eliminating cells that might go on to develop into a cancer

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Couraud S, Cortot AB, Pivot XB, Touboul C, Lhomel C, Blay J-Y, et al

Direct Toxic Effects of Cigarette Smoke on Intestinal Milieu/Autoimmunity While there is little doubt, as this review has already demonstrated, that smoking is detrimental to treatment outcomes in IBD based on a multitude of observational data, there are remarkably few studies that have explored the underlying mechanisms of which and how particular constituents of tobacco smoking affect the intestinal milieu and/or relevant immune-inflammatory pathways