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As of 2019, the US FDA found that there were 18.5 million people in the US who smoked menthol cigarettes

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The hyperpolarization of POU2F3 and FOXI1 KO cultures could result from disruption of ionocyte-enriched CFTR, which would be consistent with CFTR mutant/KO data from mice and human cell cultures 61,62 , as well as nasal potential difference measurements in individuals with cystic fibrosis 63

A regulatory system should also raise the costs and increase the consequences for those who are noncompliant, which requires an effective enforcement regime