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Nicotine alone has vasoconstrictor effects on the gums, but it avoids most of the damage (combustion, tar, direct irritation)

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Image from the United States Patent Office 1934 Pneumostat This device is known as the Pneumostat

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Tobacco harm reduction (THR), the substitution of low-risk nicotine products for cigarette smoking, is a realistic strategy for smokers who have difficulty quitting