The decreased apoptotic population observed in both 2D and organoid systems supports the idea that continuous oxidative pressure selects for stress-resistant subpopulations, consistent with early adaptive changes preceding premalignant adaptation in smoking-related airway lesions 19
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[110] E-cigarette parts, including exposed wires, wire coatings, solder joints, electrical connectors, heating element material, and vitreous fiber wick material, account for the second significant source of substances, to which users may be exposed
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