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The strength of association as measured in the BPRF framework was not sensitive to any additional restrictions we applied to the input data, meaning that the one-star rating was still observed when we subset the data to prospective cohorts, never-smoking samples and a combination of the two (Extended Data Fig

Associations between tobacco smoking and mortality: a sex-stratified cohort analysis Alexandre Valle European Journal of Public Health 25

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Therapeutic implications of germline testing in patients with advanced cancers