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Although both neutrophils and gMDSCs were shown to exhibit phenotypic and functional similarities 135 , tumor-supporting role of nicotine-activated neutrophils provide direct experimental proof that distinguish them from the immunosuppressive function of gMDSCs reported in their study

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Despite this rather in-depth knowledge concerning single environmental factor exposure in the skin-aging phenomenon, very little is known about the effects that could result from a concomitant exposure to several environmental factors, nor about the mechanisms involved

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