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This reduction in may lead to the translocation of Parkin to mitochondria, where it ubiquitinates Mfn1 and Mfn2, thereby targeting these proteins for proteasomal degradation and finally leading to removal of damaged mitochondria during mitophagy (Ni et al
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and the world cigarettes are known to contribute to increased susceptibility due to their effects on the heart, lungs, and blood vessels