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The methodology was based on comparing the therapeutic index of the substances, which was defined as the ratio of the median lethal dose (LD50) to the median effective dose (ED50)

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45,46 TAMs compose 50% of the total cell population in situ 47 and are primarily derived from cytokine-recruited macrophages that are secreted by TME stromal cells and cancer cells, and include CCL2, CCL5, and CSF1

However, e-cigarette promoting trade bodies, users and other stakeholders slammed the move to ban the "alternative" smoking device, alleging it was a "draconian" step taken in haste to protect the conventional cigarette industry and alleged that people are being deprived of a safer alternative to smoking

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