Knowing the distinction between tobacco and nicotine means understanding what you are (and arent) using
Cerd, M., Mauro, C., Hamilton, A., Levy, N
1,2 Other rare but serious cardiovascular conditions that can be caused by smoking include: Peripheral artery disease (and peripheral vascular disease) : A condition in which the narrowing of blood vessels results in insufficient blood flow to arms, legs, hands, and feet
In practice, the bigger issue is clarity
Based on a power calculation using the Clincalc.com (ClinCalc LLC, Arlington Heights, IL, USA) sample size calculator with an assumed average BP of 120 mmHg, a BP variability of 5 mmHg, a clinically relevant difference of 6 mmHg, an enrollment ratio of 3, an alpha of 0.05, and a power of 80%, at least 28 participants, of which at least 7 in each of the cessation and relapse groups, were to be included