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Current smoking remained rather stable between 1999 and 2000 and 20132014, amounting 19.5 and 20.4% of participants, respectively ( p = 0.137), although there was a gradual decrease in the percentage of former smokers (25.926.9% between 1999 and 2000 and 20032004 vs 23.1% in 20112012 and 20132014, p 700 pmol/l