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You know, in the book we talk about the example of Michael Phelps

Feder-Mengus C, Ghosh S, Weber WP, Wyler S, Zajac P, Terracciano L, et al

Reactive oxygen species stimulated pulmonary epithelial cells mediate the alveolar recruitment of fasL(+) killer B cells in LPS-Induced acute lung injuries

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For example, while we emphasize the importance of considering pack years to estimate cigarette smoke exposure, we recognize the potential for unmeasured confounding that is not captured by pack years, which has been shown to be an imperfect measure of overall cigarette smoking history