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However, sensitivity analyses were conducted to investigate the impact on the main results of additional exclusion of individuals with a history of admission to hospital with chronic obstructive pulmonary disease or other respiratory illnesses (defined as an admission to hospital with ICD-10-AM diagnosis codes J40 to J44 and J47 in any of the 55 diagnostic fields) in the 6 years prior to completing the baseline 45 and Up Study questionnaire

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Mediation analysis This study utilized the two-step MR to analyze the mediation effect 15,16

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