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A 2021 review in Frontiers in Endocrinology established that nicotine disrupts gut microbial diversity and composition inducing dysbiosis, an imbalance associated with obesity, type 2 diabetes, non-alcoholic fatty liver disease, atherosclerosis, and autoimmune disease

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and (e) in a manner that does not obstruct any information that is required by or under an Act of Parliament to appear on the package

India has the highest prevalence of oral cancer in the world (19/100, 000 population)