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De nombreux pays interdisent les produits contenant de la nicotine , comme le Japon, le Mexique, Hong Kong, la Malaisie et la Norvge (sauf ordonnance mdicale)

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Comprehensive genomic analyses have revealed a distinct tobacco-related mutational signature in liver tumors of smokers, characterized by cytosine-to-adenine base substitutions, dinucleotide alterations, and guanine adduct formation, patterns resembling those observed in lung and head-and-neck cancers [38,39,40]

Therefore, based on GBD 2021 data, this study provides an in-depth analysis of epidemiologic characteristics, risk factors, projections, and trends in the burden of disease of LC in MAOP, especially in the age subgroups