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Although the penetrance and relevance of each PV varies, a recent study found moderate to high penetrance PVs in 4.3% of a 5118 NSCLC cohort of varied smoking statuses, and this correlated with family history of any cancer as well as age of diagnosis before the age of 55 [77]
This is the major contributor to the teeth problem associated with vaping
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However, as in our previous reports using ketamine/xylazine,3436 as well as our prior study unrelated to smoke in which isoflurane was used,52 negative control groups showed no significant alteration of FMD from preintervention to postintervention, and the relative responses of experimental and control groups have been consistent and reproducible
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