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Studies of peripheral blood lymphocytes have also shown modified telomerase expression in smokers with CD [54]

in vivo these phenotypes exist as part of a spectrum and many of the M1/M2 markers are co-expressed on the same macrophages, such as CD206 ubiquitously expressed by all pulmonary macrophages.14 CS exposure and AM recruitment Increased AM and neutrophil chemotaxis Smoking induces an increase in immune cells within the lung (45 fold), as assessed by bronchoalveolar lavage (BAL)19 with most of the increase attributed to the AM cellularity.20 The increased cellularity of both AM and neutrophils may be explained by chemotactic factors generated in the lung