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NCCVF was high and periodic in pre-nicotine conditions, consistent with blood flow being highly correlated with the rhythmic heartbeat

"Smoking as a risk factor for Alzheimer's disease: contrasting evidence from a systematic review of case-control and cohort studies"

La Vie qu'on voulait, Grasset, 2013

Our study used devices with known nicotine delivery profiles, which allowed us to effectively compare how the varying levels of nicotine in a device might affect user nicotine dependence and ability to reduce cigarette consumption. The researchers broke the participants into four distinct groups, and provided them with either an e-cigarette that contained 0, 8, or 36 mg/mL of nicotine, or a cigarette substitute that didnt contain any nicotine at all

I smoked menthol so the mint almost covered the taste of the cigarette except that it didnt, it tasted rank and my breathing got worse and worse