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At most, they may be a good alternative for ex-smokers, so they dont go back to smoking tobacco cigarettes. However, Ricciardi did also note that electronic cigarettes proved safe for consumption during the 12-month period of the presented study

Smoking-related macrophage reprogramming may increase synovitis, strengthen cytokine and chemokine signaling, and promote catabolic crosstalk with cartilage, which may lead to a more inflammatory OA phenotype