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Table of Contents How Fluconazole and Suboxone Are Metabolized To fully understand the answer to Can I take fluconazole with Suboxone, you need to know how these substances are metabolized in the body 3 Major Symptoms to Watch For When You Combine Fluconazole and Suboxone Here are the symptoms of using both medications: Drowsiness, as it depresses the central nervous system Dizziness due to slow brain functioning Respiratory distress due to the decline in oxygen levels 2 Ask an Expert