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Rates remain high among low-income Americans (24.4 percent), rural residents (27 percent), people with disabilities (21.5 percent), and workers in construction and extraction jobs (around 29 percent)

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At clinical concentrations, pretomanid does not inhibit major CYP isoenzymes, including CYP1A2, CYP2C8, CYP2C9, CYP2C19 or CYP2D6, and does not induce CYP2C9 or CYP3A4, limiting the potential for DDI trough CYPs

However, if your symptoms don't improve within a few days, or you are concerned about them, call a healthcare provider

Feeling Cool/Rebellious/Tough: Often used to project a nonchalant, rebellious, or "cool" image, harkening back to classic Hollywood portrayals of smokers