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Following a rigorous science-based review of the premarket tobacco product applications (PMTAs) submitted by the company, the agency determined that authorizing these reduced nicotine products for sale in the US is appropriate for the protection of the public health because of, among several key considerations, the potential to reduce nicotine dependence in addicted adult smokers, who may also benefit from decreasing nicotine exposure and cigarette consumption

Therefore, it is plausible that CXCL12 produced by pericytes contributes to angiogenesis by promoting endothelial cell proliferation in CNV

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