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The ROS produced are converted to peroxynitrite, which has a very strong cytotoxic effect when combined with NO, resulting in direct damage to vascular wall cells and a decrease in the biological activity of NO in vascular endothelial cells and vascular smooth muscle cells [68]

11 When intracellular cholesterol is excessive, it leads to the formation of specific sterols, thereby activating the liver X receptor (LXR)-retinoid X receptor (RXR) heterodimeric transcription factor, which promotes cholesterol efflux from cells by upregulating the expression of ABCA1 and ABCG1

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Making quitting tobacco part of an overall approach to treatment and wellness

Robinson et al