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During the London plague of 1665 children were instructed to smoke in their schoolrooms

In 1599, a Swiss traveller to England was astounded at what was quickly becoming a London-wide addiction amongst the elite and middling-sort: They always carry the instrument on themlighting up on all occasions: at the play, in the taverns, or elsewhere

Research confirms that pouches in the 2030mg range can produce plasma nicotine concentrations comparable to cigarettes [3]

M., Hoek, J., Edwards, R., & Maclaurin, J

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