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A randomized trial of dual use of tobacco and e-cigarettes (with different flavors) showed a decrease in harmful or potentially harmful biomarkers for polycyclic aromatic hydrocarbons (PAHs such as pyrene) in users of electronic cigarettes, which were reduced by 6269%

[ 33 ] This underscores the need for strong age-verification requirements and strong enforcement efforts, including, as study authors suggest, an increase in the number and frequency of FDA compliance checks

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be applied at the retail or wholesale level