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This may reflect the difference in the proportion of ever-smokers (50.3% in our study, 72.6% in their study), since KRAS G12C was found to be more strongly associated with smoking-associated signature four in lung adenocarcinoma than other KRAS mutations.29 To explain why pack-years was superior to smoking duration in predicting the frequencies of KRAS mutations, we divided KRAS subtypes (G12A, G12C, G12D, G12V) into four groups according to smoking duration and pack-years

It would therefore be very helpful to identify those most susceptible to lung cancer early on so that preventative measures can be instituted

"That made it difficult to assess whether the carcinogen found in the urine was actually from the e-cigarette use or from the cigarette use." Further research is needed, said Bjurlin, who wants to determine the threshold of exposure to carcinogens that would lead to development of bladder cancer or other cancer types

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