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Cerulein is an orthologue of the hormone cholecystokinin (CCK) and, when given at supraphysiologic concentrations (10-100x that required to induce physiological responses), it causes typical pancreatitis responses (zymogen activation, histological/morphological changes) in isolated acinar cells or live animals
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PMID 1539521
They also avoid tobacco entirely, which is a plus for anyone trying to quit tobacco
Systematic review of the health effects of modified smokeless tobacco products
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