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Aim In this paper we review the evidence suggesting the effects of cigarette smoking on the respiratory epithelium and its role in the pathogenesis in chronic rhinosinusitis

Study 6 This study assessed the effect of an additional 12 weeks of CHANTIX therapy on the likelihood of long-term abstinence

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The brain adapts and gets used to the feeling, leading to more cravings for nicotine when not using tobacco, according to the study Biological basis of tobacco addiction: Implications for smoking-cessation treatment. Early Exposure to Nicotine: Individuals who start smoking or using tobacco at a young age are more likely to develop a stronger addiction

These could indicate an actual infection, not smoker's flu