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[DOI] [PMC free article] [PubMed] [Google Scholar] 100.Shihadeh A, Schubert J, Klaiany J, El Sabban M, Luch A, Saliba NA

42 The mechanism by which tobacco products (either smoking or smokeless) have elevated the risk of renal disorders may be through enhancing the synthesis of free radicals which may result in alterations of glomerular function leading to elevated levels of urea and creatinine in tobacco chewers and smokers

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This is important given the unprecedented degree of aging of the world's human population, the fact that many people continue to smoke into old age 2 and the possibility that stopping early enough may help toward delaying dementia if it leads to a reversal of cortical thinning effects of smoking