tobacco original use North America's Earliest Smokers May Have Helped Launch the Agricultural Revolution Tobacco Product Use Among Adults

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Conclusion The study demonstrates that smoking significantly increases strop development risk, primarily due to exposure to carbon monoxide and nicotine

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Because active smoking is strongly associated with increased disease risk, greater misclassification of an actively smoking spouse as a non-smoker among spouses of smokers compared with spouses of nonsmokers would lead to risk estimates for spousal smoking that are biased upward by the effect of active smoking