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Inhibition of heme oxygenase-1 partially reverses the arsenite-mediated decrease of CYP1A1, CYP1A2, CYP3A23, and CYP3A2 catalytic activity in isolated rat hepatocytes

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10.1136/tc.2005.015388

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They were randomized (1:1 ratio) to either (1) continue to smoke the same 11.6 mg nicotine SPECTRUM research cigarettes they smoked in Baseline II for 18 additional weeks (UNC) or (2) switch to identical appearance cigarettes with progressively reduced nicotine content (RNC)