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Several studies have shown that nicotine can improve cognitive impairment in Alzheimer's disease by enhancing protein kinase B activity and stimulating phosphoinositide 3-kinase/Akt signaling pathways, which are crucial for learning and memory processes

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Exposure to cigarette smoke leads to increased permeability of the respiratory epithelium, mucous overproduction, impaired mucociliary clearance, enhanced release of pro-inflammatory cytokines and chemokines with consecutive recruitment of macrophages and neutrophils, as well as altered pathogen sensing and clearance